Abstract

The aim of this thesis is twofold: 1. to investigate the prognostic value of intracoronary imaging and blood biomarkers in patients with coronary artery disease; 2. to improve risk prediction and management of patients with cardiogenic shock from acute myocardial infarction. We concluded that intracoronary imaging of atherosclerosis using intravascular ultrasound virtual histology and near-infrared spectroscopy can predict cardiovascular outcome in patients with established coronary artery disease. Blood biomarkers of inflammation, unfavorable lipid profile, elevated coagulation and myocardial necrosis are associated with high-risk coronary plaque characteristics. Proteomics- and lipidomics-based research carry potential to reveal novel blood biomarkers of coronary artery disease. Patients with cardiogenic shock from acute myocardial infarction have a high in-hospital mortality. It is important to search for treatment strategies that can lower mortality of such patients. The fact that survivors have a favorable long-term clinical outcome is encouraging. Intra-aortic balloon pump counterpulsation remains the method of first choice for mechanical circulatory assistance in cardiogenic shock, despite the lack of a proven survival benefit.

Additional Metadata
Keywords coronary artery disease, atherosclerosis, intracoronary imaging, biomarkers, cardiogenic shock
Promotor H. Boersma (Eric)
Publisher Erasmus University Rotterdam
Sponsor The research described in this thesis was supported by a grant of the Dutch Heart Foundation (DHF-2009B091)
ISBN 978-94-6169-650-2
Persistent URL hdl.handle.net/1765/78104
Citation
Cheng, J.M. (2015, May 12). Coronary Artery Disease: from Atherosclerosis to Cardiogenic Shock. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/78104