Memory Formation and Suppression through AMPA Receptor Dependent Synaptic Plasticity

Abstract

Our biological success depends on our capacity to adapt to a dynamic environment. Through experience we are able to acquire, modify or reinforce skills, values or preferences, which will determine our future behavior. This process is defined as learning and it is well established that our brain is the key structure for it to take place. However, deciphering the neural mechanisms enabling learning is one of the biggest challenges of modern neuroscience. In my thesis with the title “Memory formation and suppression through AMPA receptor dependent synaptic plasticity” I start with introducing the model systems that we use to study memory formation, namely the mouse cerebellum and hippocampus. In a next step I provide information about suggested mechanistic theories for learning and the key molecular pathways known to be involved such model structures. I will finish this chapter by introducing the three experimental chapters that form the core of my thesis.