Oncolytic Newcastle Disease Virus as treatment for pancreatic cancer

Abstract

In this thesis, experiments are presented that were undertaken to develop oncolytic NDV for the treatment of pancreatic adenocarcinoma. Oncolytic viruses (OVs), reported first halfway the previous century, have undergone a tremendous evolution from anecdotal experimental and clinical efficacy to state-of-the-art clinical trials employing recombinant viruses in the last decade. With the advent of reverse engineering techniques, modifications attributing to efficacy and safety have marked the introduction of new generations of recombinant OVs.