2015-09-22
Developmental dynamics of transcription and genome architecture
Publication
Publication
De dynamiek van transcriptie en genoom architectuur tijdens de ontwikkeling
Abstract
Regulation of gene expression is necessary for the control of complex developmental processes. The genome has to shape in specific conformations to fit inside the nucleus and to tether specific regulatory elements to their target genes. Although the linear composition of many genomes is largely known, their three dimensional (3D) organization and dynamics are largely unknown. Hence, in order to unravel gene regulation, it is necessary to understand the chromatin structure and organization. Furthermore, developmental procedures are controlled by complex combinatorial transcription factor (TF) networks. Hence, unveiling those networks will provide a better insight towards understanding those developmental procedures. The work described in this thesis aims to study the genome conformation/interactome and their effect on gene regulation and to unveil the role of transcription factor proteins (TFs) in complex developmental processes.
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F.G. Grosveld (Frank) | |
Erasmus University Rotterdam | |
hdl.handle.net/1765/78885 | |
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Organisation | Erasmus MC: University Medical Center Rotterdam |
Kolovos, P. (2015, September 22). Developmental dynamics of transcription and genome architecture. Retrieved from http://hdl.handle.net/1765/78885 |