Modulography is an experimental elasticity imaging method. It has potential to become an all-in-one in vivo tool (a) for detecting vulnerable atherosclerotic coronary plaques, (b) for assessing information related to their rupture-proneness and (c) for imaging their elastic material composition. Modulography determines a cross-sectional image of the elasticity distribution (=Young's modulus) from deformation (=strain) that is processed from intravascular ultrasound (IVUS) measurements. By looking at this image, cardiologists and other researchers can directly identify and characterize soft and stiff plaque-components of thin-cap fibroatheromas and of heterogeneous plaques. As a diagnostic and pharmaceutical screening tool, Modulography may contribute to the reduction of heart attacks and strokes, which are the number-one killers in westernized societies.

atherosclerosis, elasticity, intravascular ultrasound (IVUS), inverse problem, tissue characterization, vulnerable plaque
A.F.W. van der Steen (Ton) , P.W.J.C. Serruys (Patrick)
Erasmus University Rotterdam
Bristol-Myers Squibb & Bristol-Myers Squibb MedicalImagingCardialysis, Dutch Technology Foundation (STW), Interuniversity Cardiology Institute of the Netherlands, Merck Sharp & Dohme BV, Netherlands Heart Foundation, Novartis Pharma AG, OrbusNeich, Pfizer, Sanofi-Aventis, Volcano Corporation
978-90-8559-172-6
hdl.handle.net/1765/7922
Erasmus MC: University Medical Center Rotterdam

Baldewsing, R. (2006, June 21). Modulography: elasticity imaging of atherosclerotic plaques. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/7922