In the present thesis the two most common peripheral nerve pathologies, peripheral nerve injury and diabetic peripheral neuropathy, were examined using preclinical animal models. Both nerve pathologies commonly lead to neuropathic pain, which is defined as pain caused by lesion or disease of the somatosensory nervous system. Manifestations of neuropathic pain features were analysed using quantitative sensory testing, electrophysiology, and skin biopsy with a focus on dynamics of epidermal innervation.

S.E.R. Hovius (Steven) , E.T. Walbeehm (Erik) , T.J.H. Ruigrok (Tom)
Erasmus University Rotterdam
Publication of this thesis was financially supported by: - Stichting Esser Course - Nederlandse Vereniging voor Plastische Chirurgie - Erasmus University Rotterdam - Van Wijngaarden Medical - Astellas B.V. - Sigma-tau B.V.
Erasmus MC: University Medical Center Rotterdam

Kambiz, S. (2015, November 25). Dynamics of Epidermal Innervation. Retrieved from