2015-09-14
Mannan-binding lectin is involved in the protection against renal ischemia/ reperfusion injury by dietary restriction
Publication
Publication
PLoS ONE , Volume 10 - Issue 9
Preoperative fasting and dietary restriction offer robust protection against renal ischemia/ reperfusion injury (I/RI) in mice.We recently showed that Mannan-binding lectin (MBL), the initiator of the lectin pathway of complement activation, plays a pivotal role in renal I/RI. Based on these findings, we investigated the effect of short-term DR (30% reduction of total food intake) or three days of water only fasting on MBL in 10-12 weeks old male C57/Bl6 mice. Both dietary regimens significantly reduce the circulating levels of MBL as well as its mRNA expression in liver, the sole production site of MBL. Reconstitution of MBL abolished the protection afforded by dietary restriction, whereas in the fasting group the protection persisted. These data show that modulation of MBL is involved in the protection against renal I/RI induced by dietary restriction, and suggest that the mechanisms of protection induced by dietary restriction and fasting may be different. Copyright:
| Additional Metadata | |
|---|---|
| doi.org/10.1371/journal.pone.0137795, hdl.handle.net/1765/79238 | |
| PLoS ONE | |
| Organisation | Department of Surgery |
|
Shushimita, S., van der Pol, P., de Bruin, R., IJzermans, J., van Kooten, C., & Dor, F. (2015). Mannan-binding lectin is involved in the protection against renal ischemia/ reperfusion injury by dietary restriction. PLoS ONE, 10(9). doi:10.1371/journal.pone.0137795 |
|
