2015
Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus
Publication
Publication
Molecular Psychiatry , Volume 20 - Issue 12 p. 1588- 1595
We investigated the genetic overlap between Alzheimer's disease (AD) and Parkinson's disease (PD). Using summary statistics (P-values) from large recent genome-wide association studies (GWAS) (total n=89 904 individuals), we sought to identify single nucleotide polymorphisms (SNPs) associating with both AD and PD. We found and replicated association of both AD and PD with the A allele of rs393152 within the extended MAPT region on chromosome 17 (meta analysis P-value across five independent AD cohorts=1.65 × 10 -7). In independent datasets, we found a dose-dependent effect of the A allele of rs393152 on intra-cerebral MAPT transcript levels and volume loss within the entorhinal cortex and hippocampus. Our findings identify the tau-associated MAPT locus as a site of genetic overlap between AD and PD, and extending prior work, we show that the MAPT region increases risk of Alzheimer's neurodegeneration.
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doi.org/10.1038/mp.2015.6, hdl.handle.net/1765/79292 | |
Molecular Psychiatry | |
Organisation | Department of Epidemiology |
Desikan, R.S. (R. S.), Schork, A.J. (A. J.), Wang, Y. (Y.), Witoelar, A., Sharma, M. (M.), McEvoy, L.K. (L. K.), … Dale, A.M. (A. M.). (2015). Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus. Molecular Psychiatry, 20(12), 1588–1595. doi:10.1038/mp.2015.6 |