The tumour itself is at least as dynamic as the fields of research aiming to understand cancer formation and optimize treatments for patients. This thesis describes experiments to study and analyse tumour motility at various levels. Cell migration was studied of tumour and endothelial cells by means of a novel migration method. Treatment of solid tumours with TNF was used to study the mechanisms of action. For EMAP-II studies from molecule to patient were performed. Mobilisation of proteins within cells and redistribution of cells within tumours was analysed.

EMAP-II, TNF-R1, cell migration, endothelial cells, melanoma, sarcoma, tumorcells
A.M.M. Eggermont (Alexander)
Erasmus University Rotterdam
BioSource, Boehringer Ingelheim Pharma GmbH, Eggermont, Prof. Dr. A.M.M. (promotor), Foundation ‘Erasmus Heelkundig Kankeronderzoek’ (SEHK)., Foundation ‘Vanderes’, J.E. Jurriaanse Stichting, Mrace Translational Research Fund (EMC), Oko-Lab (www.microscopeincubator.com), Tebu-Bio
978-90-90-20874-9
hdl.handle.net/1765/7931
Erasmus MC: University Medical Center Rotterdam

van Horssen, R. (2006, September 6). Tumor Motility: Cell migration analysis and effects of EMAP-II on TNF antitumour activities. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/7931