Efficient differentiation of human mesenchymal stromal cells (MSCs) into osteoblasts is crucial to accelerate bone formation in regenerative therapies. The use of the extracellular matrix (ECM) has received increased attention as a natural 3D microenvironment. The ECM may mimic the in vivo tissue architecture, due to its unique composition and its physical properties, that modulate the differentiation fate of the seeded cells. Thereby, strategies combining cell-secreted ECMs and MSCs have been proposed to improve MSC properties for bone regeneration.

Erasmus MC: University Medical Center Rotterdam

Baroncelli, M., Alves, R., Eijken, M., Demmers, J., van de Peppel, J., & van Leeuwen, H. (2015). In-Vitro Models of Devitalized Extracellular Matrix to Modulate the Osteogenic Potential of Mesenchymal Stromal Cells. In Proceedings of the 24th NBTE Annual Meeting, Lunteren, The Netherlands, 3 & 4 December 2015 (pp. 8–8). Retrieved from http://hdl.handle.net/1765/79580