2016-02-08
Changes in heterosubtypic antibody responses during the first year of the 2009 A(H1N1) influenza pandemic.
Publication
Publication
Scientific Reports (Nature) , Volume 6
Seropositivity to avian influenza (AI) via low-level antibody titers has been reported in the general population and poultry-exposed individuals, raising the question whether these findings reflect true infection with AI or cross-reactivity. Here we investigated serological profiles against human and avian influenza viruses in the general population using a protein microarray platform. We hypothesized that higher antibody diversity across recent H1 and H3 influenza viruses would be associated with heterosubtypic reactivity to older pandemic- and AI viruses. We found significant heterogeneity in antibody profiles. Increased antibody diversity to seasonal influenza viruses was associated with low-level heterosubtypic antibodies to H9 and H7, but not to H5 AI virus. Individuals exposed to the recent 2009 A(H1N1) pandemic showed higher heterosubtypic reactivity. We show that there is a complex interplay between prior exposures to seasonal and recent pandemic influenza viruses and the development of heterosubtypic antibody reactivity to animal influenza viruses.
| Additional Metadata | |
|---|---|
| doi.org/10.1038/srep20385, hdl.handle.net/1765/79807 | |
| Scientific Reports (Nature) | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
|
Freidl, G., van den Ham, H. J., Boni, M., de Bruin, E., & Koopmans, M., D.V.M. (2016). Changes in heterosubtypic antibody responses during the first year of the 2009 A(H1N1) influenza pandemic. Scientific Reports (Nature), 6. doi:10.1038/srep20385 |
|
