In the Netherlands, there has been a tradition of conducting so-called Costs-of-Illness (COI) studies. In the Dutch COI studies total healthcare expenditures (HCE) in different healthcare settings in the Netherlands are uniquely attributed to disease categories, healthcare provider categories, specified by sex and age. COI studies in the Netherlands have been conducted for years 1994, 1999, 2003, 2005, 2007 and 2010. This report described the results of a study with the aim to a) predict HCE for the years 1995-1998, 2000-2002, 2004, 2006, 2008-2009 and b) forecast HCE for the years 2011-2015.