The transplantation of human livers to save patients with end-stage liver diseases is always accompanied by immune responses trying to eliminate the transplanted organ, which are shaped and regulated by several environmental and genetic factors. Therefore, a better knowledge of the immune regulation in patients after liver transplantation is crucial to facilitate developing interventions to achieve a better long-term patient outcome. In this thesis, we study environmental and genetic factors that influence alloreactivity in liver transplant patients, investigate their impact on clinical outcomes, and suggest novel perspectives that may help to personalize patient immunosuppressive management to minimize adverse effects of life-long standard immunosuppressive medication.

Additional Metadata
Promotor H.J. Metselaar (Herold) , J. Kwekkeboom (Jaap)
Publisher Erasmus University Rotterdam
Sponsor Printing of this thesis was supported by: Erasmus University Rotterdam; Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, The Netherlands, The Foundation for Liver and Gastrointestinal Research.
ISBN 978-94-6233-230-0
Persistent URL hdl.handle.net/1765/79898
Citation
Shi, X-L. (2016, March 8). New insights in immune regulation after liver transplantation. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/79898