The aims of this thesis are:
• To study the extent of oral drugs used in neonatal and pediatric intensive care.
• To review the current knowledge of age-related variation in processes that govern oral drug absorption.
• To review the current literature on human membrane transporters during childhood.
• To assess the ontogeny of relevant human membrane transporters gene and protein expression in pediatric intestinal and hepatic tissues.
• To study the feasibility of [14C]-labeled microdosing studies in children.
• To investigate the effect of age on the combined intestinal and hepatic glucuronidation and sulfation in young children, using a paracetamol microdosing study.

Additional Metadata
Promotor D. Tibboel (Dick) , S.N. de Wildt (Saskia)
Publisher Erasmus University Rotterdam
Sponsor The studies described in this thesis were supported by: Netherlands Organization for Health Research and Development (ZonMw) – research grant (113202007) Novartis – investigator initiated grant Travel grants from: Erasmus Trustfonds, Dutch Society of Clinical Pharmacology and Biopharmaceutics, F1000 review platform
ISBN 978-94-6169-823-0
Persistent URL
Mooij, M.G. (2016, March 22). Evolution in Pediatric Pharmacology: Microdosing, metabolism, and membrane transporters. Erasmus University Rotterdam. Retrieved from