Adrenal Tumours: Histopathological and Molecular Genetic Perspectives

Revolutionary breakthroughs, stemming from genetic and genomic studies, have resulted not only in understanding the pathobiology of tumours, but also increased the roles of pathologists in helping to guide patient care. The evolving role of histopathology in tumours originating from the adrenal gland and extra-adrenal paraganglia encompasses
(1) differential diagnosis,
(2) prognosis,
(3) identification of clues to occult hereditary disease and
(4) triaging of patients for optimal genetic testing by immunohistochemistry (IHC).

The aim of the current thesis was to contribute into this fascinating field of histopathology and hence elucidate various aspects in terms of diagnostics, prognostics and molecular genetics of tumours originating from the adrenal gland and extra-adrenal paraganglia.