Isotype Defects

van der Burg, Mirjam; Weemaes, Corry; Cunningham-Rundles, Charlotte

doi:10.1016/B978-0-12-405546-9.00016-9

Isotype defects are defined as partial antibody deficiencies in which only one immunoglobulin (Ig) isotype or one Ig isotype subclass is lacking. In these patients the absolute numbers of peripheral blood B cells are normal (in contrast to other primary antibody deficiencies described in previous chapters). After a brief overview of structure and function of immunoglobulins, the six disorders caused by isotype defects will be introduced and described in individual sections of this chapter.

Additional Metadata
Keywords	Ig heavy chain deletion, IgA, IgA with IgG subclass deficiency, IgG, IgG subclass deficiency, IgM, Igκ or Igλ deficiency, Immunoglobulin, Isotype, Selective IgA deficiency, Selective IgM deficiency
Persistent URL	doi.org/10.1016/B978-0-12-405546-9.00016-9, hdl.handle.net/1765/81131
Rights	no subscription
Organisation	Department of Immunology
Citation APA Style AAA Style APA Style Cell Style Chicago Style Harvard Style IEEE Style MLA Style Nature Style Vancouver Style American-Institute-of-Physics Style Council-of-Science-Editors Style BibTex Format Endnote Format RIS Format CSL Format DOIs only Format	van der Burg, M., Weemaes, C., & Cunningham-Rundles, C. (2014). Isotype Defects. doi:10.1016/B978-0-12-405546-9.00016-9

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