Isotype defects are defined as partial antibody deficiencies in which only one immunoglobulin (Ig) isotype or one Ig isotype subclass is lacking. In these patients the absolute numbers of peripheral blood B cells are normal (in contrast to other primary antibody deficiencies described in previous chapters). After a brief overview of structure and function of immunoglobulins, the six disorders caused by isotype defects will be introduced and described in individual sections of this chapter.

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Keywords Ig heavy chain deletion, IgA, IgA with IgG subclass deficiency, IgG, IgG subclass deficiency, IgM, Igκ or Igλ deficiency, Immunoglobulin, Isotype, Selective IgA deficiency, Selective IgM deficiency
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van der Burg, M, Weemaes, C.M.R, & Cunningham-Rundles, C. (2014). Isotype Defects. doi:10.1016/B978-0-12-405546-9.00016-9