Zika virus (ZIKV), a mosquito-borne flavivirus closely related to yellow fever virus and dengue virus, is currently causing a large outbreak in the Americas. Historically, ZIKV infection was considered a sporadic, relatively mild disease characterised by fever, maculopapular rash, conjunctivitis and often arthralgia. However, current observational studies suggest that ZIKV may cause more severe neurological sequelae such as Guillain-Barre syndrome, and birth defects, mainly microcephaly, in babies of whom the mother was infected with ZIKV during pregnancy. This article provides a clinically focussed overview of ZIKV, with emphasis on the current outbreak, clinical manifestations, diagnostic tools and caveats.

Aedes, Americas, Flavivirus, Microcephaly, Outbreak, Zika virus
The Netherlands Journal of Medicine
Department of Virology

Goeijenbier, M, Slobbe, L, Eijck, A.A, De Mendonça Melo, M, Koopmans, M.P.G, D.V.M., & Reusken, C.B.E.M. (2016). Zika virus and the current outbreak: An overview. The Netherlands Journal of Medicine (Vol. 74, pp. 104–109). Retrieved from http://hdl.handle.net/1765/81448

Additional Files
available online