The angiotensin II type 2 receptor for pain control
Cell , Volume 157 - Issue 7 p. 1504- 1506
All well-known deleterious effects of angiotensin (Ang) II, including vasoconstriction, inflammation, water and salt retention, and vascular remodeling, are mediated via its type 1 (AT1) receptor. This explains why AT1 receptor blockers (ARBs) and inhibitors of Ang II synthesis, such as ACE inhibitors and renin inhibitors, are beneficial for cardiovascular disease. Yet, Ang II has a second receptor, the Ang II type 2 (AT2) receptor, the function of which, even after over 20 years of research, remains largely unknown. In this issue, Marion et al. provide a new chapter to the AT2 receptor story.
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Danser, A.H.J, & Anand, P. (2014). The angiotensin II type 2 receptor for pain control. Cell (Vol. 157, pp. 1504–1506). doi:10.1016/j.cell.2014.05.030