2015-11-01
MARK-AGE biomarkers of ageing
Publication
Publication
Mechanisms of Ageing and Development , Volume 151 p. 2- 12
Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.
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| doi.org/10.1016/j.mad.2015.03.006, hdl.handle.net/1765/81549 | |
| Mechanisms of Ageing and Development | |
| Organisation | Department of Molecular Genetics |
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Bürkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, J., Zondag, G., Hoeijmakers, J., Toussaint, O., Grubeck-Loebenstein, B., Mocchegiani, E., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Dollé, M., Salmon, M., Kristensen, P., Griffiths, H. R., Libert, C., Grune, T., … Aspinall, R. (2015). MARK-AGE biomarkers of ageing. Mechanisms of Ageing and Development, 151, 2–12.https://doi.org/10.1016/j.mad.2015.03.006 |
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