Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

Ageing biomarkers, Human studies, MARK-AGE,
Mechanisms of Ageing and Development
Department of Molecular Genetics

Bürkle, A, Moreno-Villanueva, M, Bernhard, J, Blasco, J, Zondag, G, Hoeijmakers, J.H.J, … Aspinall, R. (2015). MARK-AGE biomarkers of ageing. Mechanisms of Ageing and Development, 151, 2–12. doi:10.1016/j.mad.2015.03.006