Aims: Elevation of a child's blood pressure may cause possible health risks in later life. There is evidence for adverse effects of exposure to air pollution and noise on blood pressure in adults. Little is known about these associations in children. We investigated the associations of air pollution and noise exposure with blood pressure in 12-year-olds. Methods: Blood pressure was measured at age 12 years in 1432 participants of the PIAMA birth cohort study. Annual average exposure to traffic-related air pollution [NO<inf>2</inf>, mass concentrations of particulate matter with diameters of less than 2.5 μm (PM<inf>2.5</inf>) and less than 10 μm (PM<inf>10</inf>), and PM<inf>2.5</inf> absorbance] at the participants' home and school addresses at the time of blood pressure measurements was estimated by land-use regression models. Air pollution exposure on the days preceding blood pressure measurements was estimated from routine air monitoring data. Long-term noise exposure was assessed by linking addresses to modelled equivalent road traffic noise levels. Associations of exposures with blood pressure were analysed by linear regression. Effects are presented for an interquartile range increase in exposure. Results: Long-term exposure to NO<inf>2</inf> and PM<inf>2.5</inf> absorbance were associated with increased diastolic blood pressure, in children who lived at the same address since birth [adjusted mean difference (95% confidence interval) [mmHg] 0.83 (0.06 to 1.61) and 0.75 (-0.08 to 1.58), respectively], but not with systolic blood pressure. We found no association of blood pressure with short-term air pollution or noise exposure. Conclusions: Long-term exposure to traffic-related air pollution may increase diastolic blood pressure in children.

Air pollution, Birth cohort, Blood pressure, Children, Traffic noise,
European Journal of Preventive Cardiology
This work was funded by the European Commission 7th Framework Programme; grant id fp7/211250 - European Study of Cohorts for Air Pollution Effects (ESCAPE)
Department of Pediatrics

Bilenko, N, van Rossem, L, Brunekreef, B, Beelen, R.M.J, Eeftens, M, Hoek, G, … Gehring, U. (2015). Traffic-related air pollution and noise and children's blood pressure: Results from the PIAMA birth cohort study. European Journal of Preventive Cardiology, 22(1), 4–12. doi:10.1177/2047487313505821