In neural networks, activity-dependent synaptic plasticity can be long lasting and bidirectional. Synapses can be potentiated (long-term potentiation (LTP)) or depressed (long-term depression (LTD)), enabling the storage (and erasure) of information at selected sets of synapses. In the cerebellum, LTD at parallel fiber to Purkinje cell synapses is believed to provide a cellular basis for forms of cerebellar motor learning. More recently described forms of LTP might, in turn, provide reversal mechanisms. This article describes cerebellar LTD and LTP from a cellular/molecular perspective and points out similarities and differences to their counterparts at hippocampal synapses.

Calcium, CaMKII, Cerebellum, Climbing fiber, Long-term depression, Long-term potentiation, Parallel fiber, PKC, Protein phosphatase, Purkinje cell,
Erasmus MC: University Medical Center Rotterdam

Hosy, E, Belmeguenai, A, & Hansel, C.R.W. (2010). Synaptic Plasticity: Cerebellum. doi:10.1016/B978-008045046-9.02042-8