Background: Recanalization of an occluded intracranial artery is influenced by temperature-dependent enzymes, including alteplase. We assessed the relation between body temperature on admission and recanalization. Methods: We included 278 patients with acute ischaemic stroke within nine hours after symptom onset, who had an intracranial arterial occlusion on admission CT angiography, in 13 participating centres. We calculated the relation per every 0.1°Celsius increase in admission body temperature and recanalization at three days. Results: Recanalization occurred in 80% of occluded arteries. There was no relation between body temperature and recanalization at three days after adjustments for age, NIHSS score on admission and treatment with alteplase (adjusted odds ratio per 0.1°Celsius, 0.99; 95% confidence interval, 0.94-1.05; p = 0.70). Results for patients treated or not treated with alteplase were essentially the same. Conclusions: Our findings suggest that in patients with acute ischaemic stroke there is no relation between body temperature on admission and recanalization of an occluded intracranial artery three days later, irrespective of treatment with alteplase.

dx.doi.org/10.1371/journal.pone.0140777, hdl.handle.net/1765/81834
PLoS ONE
Erasmus MC: University Medical Center Rotterdam

Geurts, M, van der Worp, H.B, Horsch, A.D, Kappelle, L.J, Biessels, G.J, Velthuis, B.K, … van der Graaf, Y. (2015). No relation between body temperature and arterial recanalization at three days in patients with acute ischaemic stroke. PLoS ONE, 10(10). doi:10.1371/journal.pone.0140777