Aim: To assess outcome after neonatal perforator stroke in the largest cohort to date.
Method: Survivors from a cohort of children diagnosed with neonatal perforator stroke using cranial ultrasound or magnetic resonance imaging were eligible for inclusion. Recovery and Recurrence Questionnaire score, presence of cerebral palsy (CP), and crude outcome were assessed, specifically (1) the ability to walk independently, (2) participation in regular education, and (3) the presence of epilepsy.
Results: Thirty-seven patients were included in the study: 14 with isolated single perforator stroke, four with multiple isolated perforator strokes, and 19 with additional brain injury. Out of 18 children with isolated perforator stroke(s), four had CP, one could not walk independently, and one developed epilepsy. The posterior limb of the internal capsule was involved in four out of 18 patients; three of these patients had CP. Of 19 children with additional brain injury, 11 had CP and three were not able to walk independently. Three out of nine children with concomitant cortical middle cerebral artery stroke developed epilepsy.
Interpretation: Perforator stroke patterns can be of use in predicting long-term outcome and for guiding counselling and surveillance. Motor outcome was favourable in children with isolated perforator stroke(s), except when the posterior limb of the internal capsule was involved.

Additional Metadata
Persistent URL dx.doi.org/10.1111/dmcn.12857, hdl.handle.net/1765/81845
Journal Developmental Medicine and Child Neurology
Citation
Ecury-Goossen, G.M, van der Haer, M, Smit, L.S, Feijen-Roon, M, Leguin, M, de Jonge, R.C.J, … Dudink, J. (2016). Neurodevelopmental outcome after neonatal perforator stroke. Developmental Medicine and Child Neurology, 58(1), 49–56. doi:10.1111/dmcn.12857