Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options
Human syndromes and mouse mutants that exhibit accelerated but bona fide aging in multiple organs and tissues have been invaluable for the identification of nine denominators of aging: telomere attrition, genome instability, epigenetic alterations, mitochondrial dysfunction, deregulated nutrient sensing, altered intercellular communication, loss of proteostasis, cellular senescence and adult stem cell exhaustion. However, whether and how these instigators of aging interrelate or whether they have one root cause is currently largely unknown. Rare human progeroid syndromes and corresponding mouse mutants with resolved genetic defects highlight the dominant importance of genome maintenance for aging. A second class of aging-related disorders reveals a cross connection with metabolism. As genome maintenance and metabolism are closely interconnected, they may constitute the main underlying biology of aging. This review focuses on the role of genome stability in aging, its crosstalk with metabolism, and options for nutritional and/or pharmaceutical interventions that delay age-related pathology.
|Age-related diseases, Antiaging interventions, DNA damage, DNA repair, Frailty, Progeria|
|This work was funded by the European Commission 7th Framework Programme; grant id fp7/259893 - The DNA damage response and breast cancer (DDRESPONSE), This work was funded by the European Commission 7th Framework Programme; grant id fp7/200880 - European Study to Establish Biomarkers of Human Ageing (MARK-AGE)|
|Organisation||Department of Molecular Genetics|
Vermeij, W.P, Hoeijmakers, J.H.J, & Pothof, J. (2016). Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options. doi:10.1146/annurev-pharmtox-010814-124316