To investigate the proportion of viral respiratory tract infections among acute undifferentiated fevers (AUFs) at primary health facilities in southern Vietnam during 2001-2005, patients with AUF not caused by malaria were enrolled at twelve primary health facilities and a clinic for malaria control program. Serum was collected on first presentation (t0) and after 3 weeks (t3) for serology. After exclusion of acute dengue infection, acute and convalescent serum samples from 606 patients were using enzyme-linked immunoassays to detect IgA, as well as IgM and IgG antibodies against common respiratory viruses. Paired sera showed the following infections: human parainfluenza virus (HPIV, 4.7%), influenza B virus (FLUBV, 2.2%), influenza A virus (FLUAV, 1.9%) and human respiratory syncytial virus (HRSV, 0.6%). There was no association between type of infection and age, sex or seasonality; some inter-annual differences were observed for influenza. Antibody prevalence, indicative of previous infections, was relatively low: HPV, 56.8%, FLUBV, 12.1%; FLUAV, 5.9% and HRSV, 6.8%.

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Southeast Asian Journal of Tropical Medicine and Public Health
Department of Virology

Phuong, H.L, Nga, T.T.T, van Doornum, G.J.J, Groen, J.M, Binh, T.Q, Giao, P.T, … de Vries, P.J. (2010). Viral respiratory tract infections among patients with acute undifferentiated fever in Vietnam. Southeast Asian Journal of Tropical Medicine and Public Health, 41(5), 1116–1126. Retrieved from