Background: End stage renal disease (ESRD) is associated with defective T-cell mediated immunity. A diverse T-cell receptor (TCR) Vβ repertoire is central to effective T-cell mediated immune responses to foreign antigens. In this study, the effect of ESRD on TCR Vβ repertoire was assessed. Results: A higher proportion of ESRD patients (68.9 %) had a skewed TCR Vβ repertoire compared to age and cytomegalovirus (CMV) - IgG serostatus matched healthy individuals (31.4 %, P < 0.001). Age, CMV serostatus and ESRD were independently associated with an increase in shifting of the TCR Vβ repertoire. More differentiated CD8+ T cells were observed in young ESRD patients with a shifted TCR Vβ repertoire. CD31-expressing naive T cells and relative telomere length of T cells were not significantly related to TCR Vβ skewing. Conclusions: ESRD significantly skewed the TCR Vβ repertoire particularly in the elderly population, which may contribute to the uremia-associated defect in T-cell mediated immunity.

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Keywords Age, CD28 null T cells, Cytomegalovirus-IgG serostatus, End stage renal disease, T cell receptor Vβ repertoire diversity
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Journal Immunity and Ageing
Huang, L, Langerak, A.W, Wolvers-Tettero, I.L.M, Meijers, R.W.J, Baan, C.C, Litjens, N.H.R, & Betjes, M.G.H. (2015). End stage renal disease patients have a skewed T cell receptor Vβ repertoire. Immunity and Ageing, 12(1). doi:10.1186/s12979-015-0055-7