Postpartum microangiopathic disorders: A case report and review of the literature
Case Reports in Women's Health , Volume 3-4 - Issue C p. 3- 6
Introduction Thrombotic microangiopathic disorders (TMA's) consist of five overlapping disorders: severe pre-eclampsia; HELLP (haemolysis, elevated liver enzyme, and low platelet count) syndrome; thrombotic thrombocytopenic purpura (TTP); haemolytic-uremic syndrome (HUS) and systemic lupus erythematosus (SLE). Although several case reports are published on TTP during pregnancy, none of them has described TTP in the postpartum period. Case presentation We present a case report that illustrates the clinical difficulties and uncertainties in diagnosing TTP in a peripartum period. After repeatedly borderline ADAMTS13 tests and deteriorating TMA abnormalities in the first 72 h postpartum, treatment with plasma filtration, fresh frozen plasma and prednisolone resulted in a quick clinical and laboratory response. Conclusion Treatment for TTP should be strongly considered in case of an on-going TMA more than 72 h after delivery.
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Wessel, C.H, Andreescu, C.E, Rombout-De Weerd, S, & Levin, M.-D. (2014). Postpartum microangiopathic disorders: A case report and review of the literature. Case Reports in Women's Health, 3-4(C), 3–6. doi:10.1016/j.crwh.2014.08.001