2016-03-29
Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error
Publication
Publication
Nature Communications , Volume 7
Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10-5), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.
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| doi.org/10.1038/ncomms11008, hdl.handle.net/1765/82311 | |
| Nature Communications | |
| Organisation | Department of Internal Medicine |
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Fan, Q., Verhoeven, V., Wojciechowski, R., Barathi, V., Hysi, P., Guggenheim, J., … Makela, K. M. (2016). Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. Nature Communications, 7. doi:10.1038/ncomms11008 |
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