Aim: To assess the predictive value of CT coronary angiography (CT-CA) in the stratification of patients with acute chest pain. Materials and methods: We enrolled 48 patients (31 males and 17 females, mean age 61.0±14yrs) with acute chest pain of suspected coronary origin, without diagnostic alterations of the ECG and/or increase of the myocardial biomarkers. Sixty-four slice CT-CA was performed within 48-72 hours. Depending on the clinical judgment, the patients were dismissed or underwent conventional coronary angiography (CAG). Patients underwent clinical follow-up at 6 months, recording the prevalence of major cardiovascular events. Results: One patient was excluded from the analysis because of poor image quality. CT-CA showed no coronary artery disease in 38.3% (18/47) of the patients, no significant coronary artery disease (<50% lumen reduction) in 31.9% (15/47) of the patients, significant coronary artery disease (≥50% lumen reduction) in 29.8% (14/47) of the patients. In 87.2% (41/47) of the patients no indication for CAG was present. In 6 (12,8%) patients with significant stenosis at CT-CA indication for CAG was present. In 50% (3/6) of these patients, CAG showed no significant coronary artery disease and in the remaining 50%(3/6) CAG was followed by percutaneous coronary angioplasty. At follow-up no major cardiovascular events were observed. Conclusions: CT-CA showed high sensitivity for the detection of significant coronary artery disease and a negative predictive value at 6-month follow-up. (

64-slice CT, Acute chest pain, Conventional coronary angiography, Coronary artery disease, Multislice computed tomography, Prognostic value
Acta Biomedica
Department of Cardiology

Maffei, E, Palumbo, A, Martini, C, Notarangelo, F, Saccò, C, Ugo, F, … Cademartiri, F. (2010). Predictive value of computed tomography coronary angiography for the evaluation of acute chest pain: Single center preliminary experience. Acta Biomedica, 81(3), 157–164. Retrieved from