Rationale: The neurotransmitter serotonin has long been implicated in the motivational control of behaviour. Recent theories propose that the role of serotonin can be understood in terms of an interaction between a motivational and a behavioural activation axis. Experimental support for these ideas, however, has been mixed. Objectives: In the current study, we aimed to investigate the role of serotonin (5HT) in behavioural vigour as a function of incentive motivation. Methods: We employed dietary acute tryptophan depletion (ATD) to lower the 5HT precursor tryptophan during the performance of a speeded visual discrimination task. Feedback valence and feedback probability were manipulated independently and cued prior to target onset. On feedback trials, fast correct responses led to either reward or avoidance of punishment, while slow or incorrect responses led to reward omission or punishment. Results: We show that behavioural responding is inhibited under high incentive motivation (i.e. high-feedback probability) at baseline 5HT levels and that lowering these leads to behavioural disinhibition, while leaving accuracy unaffected. Surprisingly, there were no differential effects of motivational valence, with 5HT depletion releasing behavioural inhibition under both appetitive and aversive motivation. Conclusions: Our findings extend current theories on the role of 5HT in behavioural inhibition by showing that reductions in serotonin lead to increased behavioural vigour only if there is a motivational drive to inhibit behaviour at baseline.

Acute tryptophan depletion, Behavioural control, Disinhibition, Motivation, Pavlovian bias, Serotonin
dx.doi.org/10.1007/s00213-014-3762-4, hdl.handle.net/1765/82548
Department of Clinical Chemistry

Den Ouden, H.E.M, Swart, J.C, Schmidt, K, Fekkes, D, Geurts, D.E.M, & Cools, R. (2015). Acute serotonin depletion releases motivated inhibition of response vigour. Psychopharmacology, 232(7), 1303–1312. doi:10.1007/s00213-014-3762-4