Background: In 2008, the European Respiratory Society Task Force proposed the terms multiple-trigger wheeze (MTW) and episodic (viral) wheeze (EVW) for children with wheezing episodes. We determined MTW and EVW prevalence, their 24-month stability and predictiveness for asthma. Methods: In total, 565 preschoolers (1-, 2- and 3-year-olds) in primary care with respiratory symptoms were followed until the age of 6 years when asthma was diagnosed. MTW status and EVW status were determined using questionnaire data collected at baseline and after one and 2 years. We distinguished 3 phenotypes and determined their 24-month stability, also accounting for treatment with inhaled corticosteroids (ICS). Logistic regression was used to analyse the phenotypes' associations with asthma. Results: Two hundred and eighty-one children had complete information. MTW and EVW were stable in 10 of 281 (3.6%) and 24 of 281 (8.5%), respectively. The odds of developing asthma for children with stable MTW and stable EVW were 14.4 (1.7-119) and 3.6 (1.2-11.3) times greater than those for children free of wheeze (for at least 1 year). ICS was associated with increased stability of MTW and EVW. Conclusions: Stable multiple-trigger and stable episodic viral wheeze are relatively uncommon. However, 1- to 3-year-olds with stable MTW are at much increased risk of asthma.

Asthma, Cohort studies, Episodic viral wheeze, Multiple-trigger wheeze, Preschool children, Primary health care,
Clinical and Experimental Allergy
Department of General Practice

Wonderen, K.E, Geskus, R.B, van Aalderen, W.M.C, Mohrs, J, Bindels, P.J.E, Van Der Mark, L.B, & ter Riet, G. (2016). Stability and predictiveness of multiple trigger and episodic viral wheeze in preschoolers. Clinical and Experimental Allergy, 46(6), 837–847. doi:10.1111/cea.12660