High-sensitive troponin-T in adult congenital heart disease
Background: Adult congenital heart disease (ACHD) patients are at risk of late complications including arrhythmias, heart failure and sudden death. High-sensitive troponin-T (hs-TnT) is the standard for diagnosing acute coronary syndrome, but is also aßociated with cardiac function and prognosis in other cardiac diseases.Weaimed to describe hs-TnT level in ACHD patients, and determine its relationship with cardiac function and other biomarkers. Methods: Consecutive ACHD patients, visiting the outpatient clinic, underwent echocardiography, exercise testing and venipuncture on the same day. Results: In total 587 patients were included (median age 33 [IQR 25-41] years, 58%male, 90% NYHA claß I). hs-TnT was above the detection limit of 5 ng/L in 241 patients (41%), of whom 47 (8%) had hs-TnT levels above the 99th percentile of normal of 14 ng/L. hs-TnT levels were highest in patients with a systemic RV or pulmonary hypertension. Patients with normal or non-detectable hs-TnT were younger (32 [IQR 24-40] years) than patient with elevated hs-TnT (42 [IQR 36-60] years, p b 0.001). The prevalence of hs-TnT ≥14 ng/L was higher in patients with NYHA ≥II (36%, p b 0.001), systemic systolic dysfunction (38%, p b 0.001), non-sinus rhythm (43%, p b 0.001) and elevated pulmonary preßures (39%, p b 0.001). hs-TnT was correlated with NT-proBNP (r = 0.400, p b 0.001). Conclusions: Hs-TnT above the 99th percentile of normal is observed in a non-trivial portion of stable ACHD patients, especially in those with a systemic RV or elevated pulmonary preßures. Since this biomarker of myocardial damage is related to NT-proBNP and ventricular function, its potential predictive value in ACHD patients seems promising and further investigation of underlying mechanisms is warranted.
|Keywords||Adult congenital heart disease, Echocardiography, Exercise testing, High-sensitive troponin t|
|Persistent URL||dx.doi.org/10.1016/j.ijcard.2015.02.027, hdl.handle.net/1765/82755|
|Journal||International Journal of Cardiology|
Eindhoven, J.A, Roos-Hesselink, J.W, van den Bosch, A.E, Kardys, I, Cheng, J.M, Veenis, J.F, … Boersma, H. (2015). High-sensitive troponin-T in adult congenital heart disease. International Journal of Cardiology, 184(1), 405–411. doi:10.1016/j.ijcard.2015.02.027