Intraoperative high-dose dexamethasone in cardiac surgery and the risk of rethoracotomy
The Annals of Thoracic Surgery , Volume 100 - Issue 6 p. 2237- 2242
Background: Cardiac surgery with the use of cardiopulmonary bypass is associated with a systemic inflammatory response. Intraoperative corticosteroids are administered to attenuate this inflammatory response. The recent Dexamethasone for Cardiac Surgery (DECS) trial could not demonstrate a beneficial effect of dexamethasone on major adverse events in cardiac surgical patients. Previous studies suggest that corticosteroids may affect postoperative coagulation and blood loss, and therefore could influence the risk of surgical reinterventions. We investigated the effects of prophylactic intraoperative dexamethasone treatment on the rate of rethoracotomy after cardiac surgery.
Methods: We performed a post-hoc additional data collection and analysis in the DECS trial. A total of 4,494 adult patients undergoing cardiac surgery with cardiopulmonary bypass were randomly assigned to intravenous dexamethasone (1.0 mg/kg) or placebo. The primary endpoint for the present study was the incidence of any rethoracotomy within the first 30 postoperative days. Secondary endpoints included the reason for rethoracotomy and the incidence of perioperative transfusion of blood products.
Results: In the dexamethasone group, 217 patients (9.7%) underwent a rethoracotomy, and in the placebo group, 165 patients did (7.3%; relative risk 1.32, 95% confidence interval: 1.09 to 1.61, p [ 0.005). The most common reason for rethoracotomy was tamponade in both groups: 3.9% versus 2.1%, respectively (relative risk 1.84, 95% confidence interval: 1.30 to 2.61, p < 0.001).
Conclusions: Intraoperative high-dose dexamethasone administration in cardiac surgery was associated with an increased rethoracotomy risk.
|The DECS trial was supported by grants 80-82310-98-08607 from the Netherlands Organization for Health Research and Development (ZonMw) and 2007B125 from the Dutch Heart Foundation, both located in The Hague, Netherlands.|
|The Annals of Thoracic Surgery|
|The Appendix can be viewed in the online version of this article|
|Organisation||Department of Anesthesiology|
Van Osch, D, Dieleman, J.M, Nathoe, H.M, Boasson, M.P, Kluin, J, Bunge, J.J.H, … Van Dijk, D. (2015). Intraoperative high-dose dexamethasone in cardiac surgery and the risk of rethoracotomy. The Annals of Thoracic Surgery, 100(6), 2237–2242. doi:10.1016/j.athoracsur.2015.06.025