Recombinant adenoviral vectors are one of the most common vectors used for somatic gene therapy secondary to their high-production titer and their high-gene transfer efficiency to a variety of tissues. This chapter provides an overview of adenovirus-based vectors for a variety of acquired diseases including infectious diseases such as tuberculosis, pneumonia, and hepatitis and chronic inflammatory diseases such as arthritis and inflammatory bowel disease. Although many of these studies are preclinical, there is a significant body of data showing efficacy of adenovirus-based vectors in relevant disease models suggesting that they may be a part of our clinical armamentarium in the future.

Adenoviral vectors, Hepatitis C virus, Inducible nitric oxide synthase, Tumor necrosis factor,
Department of Immunology

Lubberts, E.W, & Kolls, J.K. (2016). Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases. doi:10.1016/B978-0-12-800276-6.00027-9