Management of children with dilated cardiomyopathy in the Netherlands: Implications of a low early transplantation rate
The Journal of Heart and Lung Transplantation , Volume 34 - Issue 7 p. 963- 969
Background The policy for listing and transplant for children with dilated cardiomyopathy (DCM) in The Netherlands has been conservative because of low donor availability. The effects of this policy on outcome are reported. Methods This was a multicenter, nationwide study performed in 148 children with DCM. The primary outcome was death or heart transplant. Results Overall, 43 patients (29%) died or were transplanted. Within 1 year of diagnosis, 21 patients died, and only 4 underwent transplantation (3 on mechanical circulatory support). The 1-year survival was 85% (95% confidence interval [CI] = 79-91), and 5-year survival was 84% (95% CI = 78-90). Transplantation-free survival at 1 year was 82% (95% CI = 75-88) and at 5 years was 72% (95% CI = 64-80). Within 1 year of diagnosis, with death as the main end-point (21 of 25, 84%), intensive care unit admission (hazard ratio = 2.6, p = 0.05) and mechanical circulatory support (hazard ratio = 3.2, p = 0.03) were risk factors (multivariable Cox analysis); inotropic support was longer in patients reaching an end-point. At >1 year after diagnosis, with transplantation as the main end-point (15 of 18, 83%), age >6 years (hazard ratio = 6.1, p = 0.02) was a risk factor. There were 56 (38%) children who recovered, 50% within 1 year of diagnosis. Recovery was associated with younger age; was similar in patients with myocarditis (43%) and idiopathic disease (41%); and was similar in patients initially admitted to the intensive care unit, admitted to the ward, or treated as outpatients. Conclusions The transplantation rate in our cohort in the first year was low, with 1-year and 5-year survival rates similar to other cohorts. Our results suggest that a conservative approach to list children for transplantation early after presentation may be justifiable except for patients with prolonged intensive care unit or mechanical circulatory support.
|cardiomyopathy, heart failure, heart transplantation, pediatric cardiology|
|The Journal of Heart and Lung Transplantation|
|Organisation||Department of Cardio-Thoracic Surgery|
den Boer, S.L, van Osch-Gevers, M, Van Ingen, G, Du Marchie Sarvaas, G.J, van Iperen, G.G, Tanke, R, … Dalinghaus, M. (2015). Management of children with dilated cardiomyopathy in the Netherlands: Implications of a low early transplantation rate. The Journal of Heart and Lung Transplantation, 34(7), 963–969. doi:10.1016/j.healun.2015.01.980