Biomarkers may be helpful in prediction of outcomes of infants with congenital diaphragmatic hernia. The predictive value of high-sensitivity troponin T and N-terminal pro-brain natriuretic peptide was investigated in 128 infants with congenital diaphragmatic hernia. After correction for multiple testing, those biomarkers did not predict severe pulmonary hypertension, death, need of extracorporeal membrane oxygenation, or bronchopulmonary dysplasia. Trial registration: Netherlands Trial Registry: 1310.

Journal of Pediatrics
Department of Neonatology

Snoek, K., Kraemer, U., ten Kate, C., Greenough, A., van Heijst, A., Capolupo, I., … Tibboel, D. (2016). High-Sensitivity Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Prediction of Outcome in Congenital Diaphragmatic Hernia: Results from a Multicenter, Randomized Controlled Trial. Journal of Pediatrics, 173, 245–249.e4. doi:10.1016/j.jpeds.2016.03.026