2016-01-15
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration
Publication
Publication
Human Molecular Genetics , Volume 25 - Issue 2 p. 358- 370
Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels.We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ~120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indelswere examined.We identified 41 genome-wide significant fibrinogen loci; of which, 18were newly identified. Therewere no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.
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| doi.org/10.1093/hmg/ddv454, hdl.handle.net/1765/83304 | |
| Human Molecular Genetics | |
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| Organisation | Department of Internal Medicine |
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de Vries, P., Chasman, D., Sabater-Lleal, M., Chen, M.-H., Huffman, J. E., Steri, M., … Dehghan, A. (2016). A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. Human Molecular Genetics, 25(2), 358–370. doi:10.1093/hmg/ddv454 |
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