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S.M. Scholl (Susy M.), M. Kamal (Maud), L. De Koning (Léanne), A. Kereszt (Attila), E.S. Jordanova (Ekaterina S.), S. Ungureanu (Sergiu), P.M.J.J. Berns (Els) and X. Sastre (Xavier)

2013-04-30

HPV pathway profiling: HPV related cervical dysplasia and carcinoma studies

Publication

Publication

Current Pharmaceutical Design , Volume 19 - Issue 8 p. 1379- 1394

Cervical cancer is the second most common malignancy among women worldwide. While more than 90% of cervical cancers carry one or more high risk HPV types, the exact relationship between HPV oncoproteins and signaling pathways alterations in cervical cancer remains to be clarified. Vaccines and targeted therapies are today considered of great potential for the improvement of patients' outcome. This review will focus on the interaction of HPV with cervical cancer pathway activations. Next generation high throughput screening technologies for molecular and protein profiling as well as innovative logistics, necessary for the implementation of the personalized care of cervical cancer patients will be discussed.

Additional Metadata
Keywords Cervical cancer, HPV, Omics, Targeted therapy, Vaccines
Persistent URL hdl.handle.net/1765/83766
Journal Current Pharmaceutical Design
Rights no subscription
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
Scholl, S. M., Kamal, M., De Koning, L., Kereszt, A., Jordanova, E. S., Ungureanu, S., … Sastre, X. (2013). HPV pathway profiling: HPV related cervical dysplasia and carcinoma studies. Current Pharmaceutical Design (Vol. 19, pp. 1379–1394). Retrieved from http://hdl.handle.net/1765/83766


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