In this manuscript we postulate as to what may have caused the rising incidence of atopic disorders. Atopic disorders are compared to other prevalent diseases with an evolutionary advantage such as sickle cell anemia and hemochromatosis. A defective skin barrier has immunological advantages in the survival from infectious diseases. Selection pressure of filaggrine mutants from tuberculosis and influenza could explain the rise of atopic disorders. We also discuss a few epiphenomena seen in the atopic immune system.

Additional Metadata
Keywords Atopy, Epiphenomena, Evolutionary medicine, Filaggrine mutation, Selection
Persistent URL hdl.handle.net/1765/83790
Journal Nederlands Tijdschrift voor Dermatologie en Venereologie
Citation
Hajdarbegovic, E, Balak, D.M.W, & Thio, H.B. (2012). The advantage of atopy. Nederlands Tijdschrift voor Dermatologie en Venereologie, 22(2), 109–112. Retrieved from http://hdl.handle.net/1765/83790