The stratum corneum (SC) is the main barrier of the skin, offering a first line of defence against external pathogens and insults. The SC of patients with atopic dermatitis (AD) has underlying barrier deficiencies, even in non-lesional sites. A defective SC barrier is more vulnerable to environmental insults, which trigger immune reactions, further deteriorating the barrier. [...]

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This work was funded by Johnson & Johnson Santé Beauté France. MO is a BBSRC David Philips fellow (BB/J013951/1). RJT acknowledges partial support from EPSRC through Career Acceleration Fellowship (EP/G007446/1).,
Journal of Dermatological Science

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