Hepatosplanchnic circulation receives almost half of cardiac output and is essential to physiologic homeostasis. Liver cirrhosis is estimated to affect up to 1% of populations worldwide, including 1.5% to 3.3% of intensive care unit patients. Cirrhosis leads to hepatosplanchnic circulatory abnormalities and end-organ damage. Sepsis and cirrhosis result in similar circulatory changes and resultant multi-organ dysfunction. This review provides an overview of the hepatosplanchnic circulation in the healthy state and in cirrhosis, examines the signaling pathways that may play a role in the physiology of cirrhosis, discusses the physiology common to cirrhosis and sepsis, and reviews important issues in management.

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doi.org/10.3748/wjg.v21.i9.2582, hdl.handle.net/1765/84382
World Journal of Gastroenterology
Department of Intensive Care

Prin, M., Bakker, J., & Wagener, G. (2015). Hepatosplanchnic circulation in cirrhosis and sepsis. World Journal of Gastroenterology (Vol. 21, pp. 2582–2592). doi:10.3748/wjg.v21.i9.2582