Hepatosplanchnic circulation receives almost half of cardiac output and is essential to physiologic homeostasis. Liver cirrhosis is estimated to affect up to 1% of populations worldwide, including 1.5% to 3.3% of intensive care unit patients. Cirrhosis leads to hepatosplanchnic circulatory abnormalities and end-organ damage. Sepsis and cirrhosis result in similar circulatory changes and resultant multi-organ dysfunction. This review provides an overview of the hepatosplanchnic circulation in the healthy state and in cirrhosis, examines the signaling pathways that may play a role in the physiology of cirrhosis, discusses the physiology common to cirrhosis and sepsis, and reviews important issues in management.

Hepatic artery buffer response, Hepatic circulation, Liver cirrhosis, Sepsis, Splanchnic circulation
dx.doi.org/10.3748/wjg.v21.i9.2582, hdl.handle.net/1765/84382
World Journal of Gastroenterology
Department of Intensive Care

Prin, M, Bakker, J, & Wagener, G. (2015). Hepatosplanchnic circulation in cirrhosis and sepsis. World Journal of Gastroenterology (Vol. 21, pp. 2582–2592). doi:10.3748/wjg.v21.i9.2582