We here report a 7 year old acute myeloid leukemia patient with persistent spiking fever likely caused by chronic echovirus 20 infection. After immunoglobulin substitution fevers subsided and the virus was cleared. Enterovirus infection should be considered in immunocompromised patients with unexplained persistent fever.

Acute myeloid leukemia, Echovirus 20, Enterovirus, Immunoglobulin therapy, Spiking fever
dx.doi.org/10.1016/j.jcv.2014.09.006, hdl.handle.net/1765/84724
Journal of Clinical Virology
Department of Pediatrics

Murk, J.L, de Vries, R.A, Geurts van Kessel, C.H, Aron, G.I, Osterhaus, A.D.M.E, Wolthers, K.C, & Fraaij, P.L.A. (2014). Persistent spiking fever in a child with acute myeloid leukemia and disseminated infection with enterovirus. Journal of Clinical Virology, 61(3), 453–455. doi:10.1016/j.jcv.2014.09.006