Cis- and trans-regulation in X inactivation
Chromosoma: biology of the nucleus , Volume 125 - Issue 1 p. 41- 50
Female mammalian cells compensate dosage of X-linked gene expression through the inactivation of one of their two X chromosomes. X chromosome inactivation (XCI) in eutherians is dependent on the non-coding RNA Xist that is up-regulated from the future inactive X chromosome, coating it and recruiting factors involved in silencing and altering its chromatin state. Xist lies within the X-inactivation center (Xic), a region on the X that is required for XCI, and is regulated in cis by elements on the X chromosome and in trans by diffusible factors. In this review, we summarize the latest results in cis- and trans-regulation of the Xic. We discuss how the organization of the Xic in topologically associating domains is important for XCI (cis-regulation) and how proteins in the pluripotent state and upon development or differentiation of embryonic stem cells control proper inactivation of one X chromosome (trans-regulation).
|Chromosoma: biology of the nucleus|
|Organisation||Department of Developmental Biology|
van Bemmel, J.G, Mira-Bontenbal, H, & Gribnau, J.H. (2016). Cis- and trans-regulation in X inactivation. Chromosoma: biology of the nucleus (Vol. 125, pp. 41–50). doi:10.1007/s00412-015-0525-x