The usefulness of genetic testing to identify high-risk patients for common multifactorial diseases is subject to debate. Optimism about the public health opportunities is counterbalanced with skepticism, since genetic factors appear to play a role in only a minority of patients with complex diseases, the number of genes involved is large, and their penetrance is incomplete (Holtzman and Marteau 2000; Vineis et al. 2001).

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hdl.handle.net/1765/8493
American Journal of Human Genetics
Erasmus MC: University Medical Center Rotterdam

Janssens, C., Pardo Silva, M. C., Steyerberg, E., & van Duijn, C. (2004). Revisiting the clinical validity of multiplex genetic testing in complex diseases. American Journal of Human Genetics, 585–588. Retrieved from http://hdl.handle.net/1765/8493