Background In this study, we evaluated long-term survival in patients treated with and without mechanical bowel preparation (MBP) before colorectal surgery for cancer. Methods Long-term outcome of patients of 2 main participating hospitals in a prior multicenter randomized trial comparing clinical outcome of MBP versus no MBP was reviewed. Primary endpoint was cancer-related mortality and secondary endpoint was all-cause mortality. Results A total of 382 patients underwent potentially curative surgery for colorectal cancer. One hundred seventy-seven (46%) patients were treated with MBP and 205 (54%) were not before surgery. Median follow-up was 7.6 years (mean 6.6, range.01 to 12.73). There was no significant difference in both cancer-related mortality and all-cause mortality in patients treated with MBP and without MBP (P =.76 and P =.36, respectively). Multivariate analysis, taking account of age, sex, AJCC cancer stage, and ASA classification, also showed no survival difference. Conclusions Our results indicate that MBP does not seem to influence long-term survival in patients surgically treated for colorectal cancer.

Colorectal cancer, Surgery, Survival,
The American Journal of Surgery
Department of Bioinformatics

Vantsant, H.P, Kamman, A, Hop, W.C.J, Van Der Heijden, M, Lange, J.F, & Contant, C.M.E. (2015). The influence of mechanical bowel preparation on long-term survival in patients surgically treated for colorectal cancer. The American Journal of Surgery, 210(1), 106–110. doi:10.1016/j.amjsurg.2014.10.022