2015
Predicting 3-year survival in older people with intellectual disabilities using a frailty index
Publication
Publication
American Geriatrics Society. Journal , Volume 63 - Issue 3 p. 531- 536
Objectives To analyze the relationship between frailty and survival in older people with intellectual disabilities (IDs). Design Population-based longitudinal observational study. Setting Three Dutch care provider services. Participants Individuals with borderline to profound ID aged 50 and older (N = 982). Measurements A frailty index (FI) including 51 health-related deficits was used to measure frailty. Mean follow-up was 3.3 years. The Cox proportional hazards model was used to evaluate the independent effect of frailty on survival. The discriminative ability of the FI was measured using a receiver operating characteristic (ROC) curve. Results Greater FI values were associated with greater risk of death, independent of sex, age, level of ID, and Down syndrome. There was a nonlinear increase in risk with increasing FI value. For example, mortality risk was 2.17 times as great (95% confidence interval (CI) = 0.95-4.95) for vulnerable individuals (FI 0.20-0.29) and 19.5 (95% CI = 9.13-41.8) times as great for moderately frail individuals (FI 0.40-0.49) as for relatively fit individuals (FI <0.20). The area under the ROC curve for 3-year survival was 0.78. Conclusion Although the predictive validity of the FI should be further determined, it was strongly associated with 3-year mortality. Care providers working with people with ID should be able to recognize frail clients and act in an early stage to stop or prevent further decline.
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doi.org/10.1111/jgs.13239, hdl.handle.net/1765/85412 | |
American Geriatrics Society. Journal | |
Organisation | Department of General Practice |
Schoufour, J., Mitnitski, A., Rockwood, K., Evenhuis, H., & Echteld, M. (2015). Predicting 3-year survival in older people with intellectual disabilities using a frailty index. American Geriatrics Society. Journal, 63(3), 531–536. doi:10.1111/jgs.13239 |