Abstract Objectives To assess the prevalence of fatigue, pain, anxiety, and depression in adults with Duchenne muscular dystrophy (DMD), and to analyze their relationship with health-related quality of life. Design Cross-sectional study. Setting Home of participants. Participants Adults (N=80) with DMD. Interventions Not applicable. Main Outcome Measures Fatigue was assessed with the Fatigue Severity Scale; pain with 1 item of the Medical Outcomes Study 36-Item Short-Form Health Survey and by interview; and anxiety and depression by using the Hospital Anxiety and Depression Scale. Health-related quality of life was assessed using the World Health Organization Quality of Life Scale-Brief Version. Associations between these conditions and quality of life were assessed by means of univariate and multivariate logistic regression analyses. Results Symptoms of fatigue (40.5%), pain (73.4%), anxiety (24%), and depression (19%) were frequently found. Individuals often had multiple conditions. Fatigue was related to overall quality of life and to the quality-of-life domains of physical health and environment; anxiety was related to the psychological domain. Conclusions Fatigue, pain, anxiety, and depression, potentially treatable symptoms, occur frequently in adults with DMD and significantly influence health-related quality of life.

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doi.org/10.1016/j.apmr.2015.02.012, hdl.handle.net/1765/85871
Archives of Physical Medicine and Rehabilitation
Department of Rehabilitation Medicine

Pangalila, R., van den Bos, G., Bartels, B., Bergen, M., Stam, H., & Roebroeck, M. (2015). Prevalence of Fatigue, Pain, and Affective Disorders in Adults With Duchenne Muscular Dystrophy and Their Associations With Quality of Life. Archives of Physical Medicine and Rehabilitation, 96(7), 1242–1247. doi:10.1016/j.apmr.2015.02.012