Prevalence of Fatigue, Pain, and Affective Disorders in Adults With Duchenne Muscular Dystrophy and Their Associations With Quality of Life
Archives of Physical Medicine and Rehabilitation , Volume 96 - Issue 7 p. 1242- 1247
Abstract Objectives To assess the prevalence of fatigue, pain, anxiety, and depression in adults with Duchenne muscular dystrophy (DMD), and to analyze their relationship with health-related quality of life. Design Cross-sectional study. Setting Home of participants. Participants Adults (N=80) with DMD. Interventions Not applicable. Main Outcome Measures Fatigue was assessed with the Fatigue Severity Scale; pain with 1 item of the Medical Outcomes Study 36-Item Short-Form Health Survey and by interview; and anxiety and depression by using the Hospital Anxiety and Depression Scale. Health-related quality of life was assessed using the World Health Organization Quality of Life Scale-Brief Version. Associations between these conditions and quality of life were assessed by means of univariate and multivariate logistic regression analyses. Results Symptoms of fatigue (40.5%), pain (73.4%), anxiety (24%), and depression (19%) were frequently found. Individuals often had multiple conditions. Fatigue was related to overall quality of life and to the quality-of-life domains of physical health and environment; anxiety was related to the psychological domain. Conclusions Fatigue, pain, anxiety, and depression, potentially treatable symptoms, occur frequently in adults with DMD and significantly influence health-related quality of life.
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Pangalila, R.F, van den Bos, G.A.M, Bartels, B, Bergen, M.P, Stam, H.J, & Roebroeck, M.E. (2015). Prevalence of Fatigue, Pain, and Affective Disorders in Adults With Duchenne Muscular Dystrophy and Their Associations With Quality of Life. Archives of Physical Medicine and Rehabilitation, 96(7), 1242–1247. doi:10.1016/j.apmr.2015.02.012