1994
Treatment of Klebsiella pneumoniae septicemia in normal and leukopenic mice by liposome-encapsulated muramyl tripeptide phosphatidylethanolamide
Publication
Publication
The effect of free muramyl tripeptide phosphatidylethanolamide (MTPPE) and liposome-encapsulated MTPPE (LE-MTPPE) on Klebsiella pneumoniae septicemia resulting from intraperitoneal bacterial inoculation was investigated in mice. When administering a single prophylactic dose at 24 h before bacterial inoculation, the percentage survival was 55% (MTPPE) or 40% (LE-MTPPE), whereas untreated control mice died. Only repeated prophylactic treatment with LE-MTPPE could further increase survival up to 85%.
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hdl.handle.net/1765/8589 | |
Antimicrobial Agents and Chemotherapy | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Melissen, P. M. B., van Vianen, W., & Bakker-Woudenberg, I. (1994). Treatment of Klebsiella pneumoniae septicemia in normal and leukopenic mice by liposome-encapsulated muramyl tripeptide phosphatidylethanolamide. Antimicrobial Agents and Chemotherapy. Retrieved from http://hdl.handle.net/1765/8589 |