Background. Dutch clinical guidelines recommend that a standard laxative treatment (SLT) should be prescribed concomitantly when starting opioid treatment to prevent opioid-induced constipation (OIC).Methods. Clinical evidence for SLT in the treatment of OIC is lacking, therefore an observational pilot study was performed to explore the efficacy and tolerability of SLT on OIC in patients treated with the opioid oxycodone.Results. Twenty-four patients (58% female, median (range) age 65 (39-92)) were included in this pilot study. The analysis showed that 9 out of 21 patients (43%) were non-responders to SLT. When also taking into consideration patients tending to develop diarrhea 75% of patients are non-responsive to SLT.Conclusion. This pilot study indicates that optimal laxative therapy (SLT) might not be effective and feasible for the prevention and treatment of OIC.

Laxatives, Observational study, Opioid induced constipation, Oxycodone, Pilot study, Reallife data
dx.doi.org/10.1586/17474124.2016.1129275, hdl.handle.net/1765/86118
Expert Review of Gastroenterology and Hepatology
Erasmus MC: University Medical Center Rotterdam

Koopmans-Klein, G, Wagemans, M.F.M, Wartenberg, H.C.H, Van Megen, Y.J.B, & Huygen, F.J.P.M. (2016). The efficacy of standard laxative use for the prevention and treatment of opioid induced constipation during oxycodone use: A small Dutch observational pilot study. Expert Review of Gastroenterology and Hepatology, 10(4), 547–553. doi:10.1586/17474124.2016.1129275