Partner notification for reduction of HIV-1 transmission and related costs among men who have sex with men: A mathematical modeling study
PLoS ONE , Volume 10 - Issue 11
Background Earlier antiretroviral treatment initiation prevents new HIV infections. A key problem in HIV prevention and care is the high number of patients diagnosed late, as these undiagnosed patients can continue forward HIV transmission. We modeled the impact on the Dutch menwho-have-sex-with-men (MSM) HIV epidemic and cost-effectiveness of an existing partner notification process for earlier identification of HIV-infected individuals to reduce HIV transmission. Methods Reduction in new infections and cost-effectiveness ratios were obtained for the use of partner notification to identify 5% of all new diagnoses (Scenario 1) and 20% of all new diagnoses (Scenario 2), versus no partner notification. Costs and quality adjusted life years (QALYs) were assigned to each disease state and calculated over 5 year increments for a20 year period. Results Partner notification is predicted to avert 18-69 infections (interquartile range [IQR] 13-24; 51-93) over the course of 5 years countrywide to 221-830 (IQR 140-299; 530-1,127) over 20 years for Scenario 1 and 2 respectively. Partner notification was considered cost-effective in the short term, with increasing cost-effectiveness over time: from €41,476 -€41, 736 (IQR €40,529-€42,147; €40,791-€42,397) to €5,773 -€5,887 (€5,134-€7,196; €5,411-€6,552) per QALY gained over a 5 and 20 year period, respectively. The full monetary benefits of partner notification by preventing new HIV infections become more apparent over time. Conclusions Partner notification will not lead to the end of the HIV epidemic, but will prevent new infections and be increasingly cost-effectiveness over time.
|This work was funded by the European Commission 7th Framework Programme; grant id fp7/223131 - Collaborative HIV and Anti-HIV Drug Resistance Network (CHAIN), This work was funded by the European Commission 7th Framework Programme; grant id fp7/233847 - Computing Real-World Phenomena with Dynamically Changing Complex Networks (DYNANETS)|
|Organisation||Department of Internal Medicine|
Nichols, B.E, Götz, H.M, van Gorp, E.C.M, Verbon, A, Rokx, C, Boucher, C.A.B, & van de Vijver, D.A.M.C. (2015). Partner notification for reduction of HIV-1 transmission and related costs among men who have sex with men: A mathematical modeling study. PLoS ONE, 10(11). doi:10.1371/journal.pone.0142576